Syntheses of spliceostatins and thailanstatins: a review

• William A. Donaldson

Beilstein J. Org. Chem. 2020, 16, 1991–2006, doi:10.3762/bjoc.16.166

• -metathesis reaction was employed in numerous syntheses, the drawbacks of this strategy include the high catalyst loading and the excess of the olefin coupling partners. To date, the most efficient strategy for the union of the fragments relies on Pd-catalyzed sp2–sp2 couplings. Structures of spliceostatins

Photovoltaic-driven organic electrosynthesis and efforts toward more sustainable oxidation reactions

• Bichlien H. Nguyen,
• Robert J. Perkins,
• Jake A. Smith and
• Kevin D. Moeller

Beilstein J. Org. Chem. 2015, 11, 280–287, doi:10.3762/bjoc.11.32

• ][25]. The reaction requires a careful balance between the initial condensation reaction and the oxidative step with either CAN or DDQ serving as the mediator. In the third reaction (Scheme 7), an intramolecular alcohol nucleophile was added to an olefin coupling reaction [26]. When a radical cation

Recent advances in the electrochemical construction of heterocycles

• Robert Francke

Beilstein J. Org. Chem. 2014, 10, 2858–2873, doi:10.3762/bjoc.10.303

• reactions is presented and discussed in this review. Keywords: anodic cyclization; electrosynthesis; heterocycle; olefin coupling; organic electrochemistry; radical cyclization; Introduction The construction of heterocyclic cores undoubtedly represents a highly important discipline of organic synthesis

• , recent efforts in electrochemical heterocycle synthesis can mostly be differentiated into anodic olefin coupling (section 1.1), radical cyclization (section 1.2), and trapping of anodically generated iminium/alkoxycarbenium ions (section 1.3). On the other hand, cycloadditions (section 2.1), sequential

• polymer films. In the context of heterocycle synthesis, a number of mediators based on organic molecules, inorganic salts and metal complexes have been used recently and their use will be discussed later on the basis of the relevant examples. 1 Intramolecular cyclizations 1.1 Anodic olefin coupling The